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Devotional images of the Madonna and Child were a mainstay of Neroccio's workshop. Working from a standard half-length format, the artist altered the composition by adding different saints according to the wishes of his clients. Here, he has inserted John the Baptist, who carries a scroll that proclaims the coming of Christ, and Mary Magdalene, who holds the jar of oil with which she anointed the feet of Jesus.
The infant Christ's nudity expresses his humanity, and therefore, the possibility of his suffering and death.