- In her most ambitious floral still life, O’Keeffe magnified the white trumpet blossoms of the jimson weed, arranging them in an exuberant composition charged with energy and movement. The radical manipulation of scale was one of the innovations of the modernist movement.
- Jimson weed, a desert plant that bloomed in the cool evening hours, thrived in the territory near O’Keeffe’s house in Abiquiu, New Mexico.
- Cosmetic entrepreneur Elizabeth Arden commissioned O’Keeffe to paint Jimson Weed for the exercise room of her Fifth Avenue Salon in New York. Imitating O’Keeffe’s four monumental blossoms, the fitness routine of the gym’s patrons included stretching and unfurling.
Elizabeth Arden commissioned the piece from the artist; Elizabeth Arden salon was purchased by Eli Lilly and Co, Indianapolis, Indiana, in 1971; Eli Lilly donated the painting to the museum in 1997.